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CCN-2013-4

MAL-078-13-01 4 3 2 1 0 0 1 2 3 4 5 6 7 8 9 10 11 12 Time in Months 2.3% 0.5%HR: 0.20 [95% CI:0.02, 1.69] CardiacDeath(%) MGuard BMS/DES P=0.099 0% vs 1.9% (P=0.06) at 30 days 0 1 2 3 4 5 6 7 8 9 10 11 120 1 2 3 4 5 6 7 8 9 10 11 12 at 30 days MGuard EPS continues to show a consistent trend in lower mortality rates over time Death at 12 Months MASTER Trial 1 year results: MGuard Outperforms BMS & DES in STEMI Patients* MASTER Acute Results*: a Significantly Superior Complete ST-Resolution (MGuard 57.8%, Control 44.7%, p = 0.008) a Significantly Superior TIMI 3 Flow (MGuard 91.7%, Control 82.9%, p = 0.006) a Zero Mortality with MGuard at 30 days (MGuard 0%, Control 1.9%, p = 0.06) Embolic Protection Stent IMPrOvInG ClInICal OuTCOMES fOr STEMI PaTIEnTS CE Marked | Not available for sale in the USA | Investigational device only in the USA *Multicenter, Randomized Trial, 433 patients, 9 countries, 50 centers, Primary Endpoint Complete ST-Resolution, Published in JACC (Stone et. al, 2012) PRIMARy EnDPoInT AChIEvED MASTER Trial 1 year results:MASTER Trial 1 year results:MASTER Trial 1 year results:MASTER Trial 1 year results:MASTER Trial 1 year results:MASTER Trial 1 year results:MASTER Trial 1 year results:MASTER Trial 1 year results:MASTER Trial 1 year results:MASTER Trial 1 year results:MASTER Trial 1 year results:MASTER Trial 1 year results:MASTER Trial 1 year results: MGuard OutperformsMGuard OutperformsMGuard OutperformsMGuard OutperformsMGuard OutperformsMGuard OutperformsMGuard OutperformsMGuard OutperformsMGuard Outperforms BMS & DES in STEMI Patients*BMS & DES in STEMI Patients*BMS & DES in STEMI Patients*BMS & DES in STEMI Patients*BMS & DES in STEMI Patients*BMS & DES in STEMI Patients*BMS & DES in STEMI Patients*BMS & DES in STEMI Patients*BMS & DES in STEMI Patients*BMS & DES in STEMI Patients*BMS & DES in STEMI Patients*BMS & DES in STEMI Patients*BMS & DES in STEMI Patients*BMS & DES in STEMI Patients*BMS & DES in STEMI Patients*BMS & DES in STEMI Patients* nEW ! 1 YearClinicalData MASTERMASTERMASTERMASTER

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